What is autosomal dominant

Y chromosome infertility , some cases of Swyer syndrome. In codominant inheritance , two different versions alleles of a gene are expressed, and each version makes a slightly different protein. Both alleles influence the genetic trait or determine the characteristics of the genetic condition. ABO blood group, alpha-1 antitrypsin deficiency.

Mitochondrial inheritance , also known as maternal inheritance, applies to genes in mitochondrial DNA. Mitochondria, which are structures in each cell that convert molecules into energy, each contain a small amount of DNA. Because only egg cells contribute mitochondria to the developing embryo, only females can pass on mitochondrial variants to their children. Conditions resulting from variants in mitochondrial DNA can appear in every generation of a family and can affect both males and females, but fathers do not pass these disorders to their daughters or sons.

Leber hereditary optic neuropathy LHON. Many health conditions are caused by the combined effects of multiple genes described as polygenic or by interactions between genes and the environment. Such disorders usually do not follow the patterns of inheritance listed above.

For more information, please see What are complex or multifactorial disorders? Disorders caused by changes in the number or structure of chromosomes also do not follow the straightforward patterns of inheritance listed above. To read about how chromosomal conditions occur, please see Are chromosomal disorders inherited?

Other genetic factors sometimes influence how a disorder is inherited. Please try again. Something went wrong on our side, please try again. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. IMG Home Autosomal dominant inheritance pattern.

Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.

Advertising and sponsorship policy Advertising and sponsorship opportunities. Clinical Trials Information. A to Z List of Cancer Drugs.

Questions to Ask about Your Treatment. Feelings and Cancer. Adjusting to Cancer. Day-to-Day Life. Support for Caregivers. Questions to Ask About Cancer. Choices for Care. Talking about Your Advanced Cancer. Planning for Advanced Cancer. Advanced Cancer and Caregivers. Questions to Ask about Advanced Cancer. Managing Cancer Care. Finding Health Care Services. Advance Directives. Using Trusted Resources. Coronavirus Information for Patients. Clinical Trials during Coronavirus.

Adolescents and Young Adults with Cancer. Emotional Support for Young People with Cancer. Cancers by Body Location. Late Effects of Childhood Cancer Treatment. Pediatric Supportive Care. Rare Cancers of Childhood Treatment.

Childhood Cancer Genomics. Study Findings. Metastatic Cancer Research. Intramural Research. Extramural Research. Cancer Research Workforce. Partners in Cancer Research. The concept of reduced penetrance is particularly important in the case of autosomal dominant cancer susceptibility genes. If a person has inherited a cancer susceptibility gene, it does not mean they will automatically develop cancer. It simply means that the person has inherited a mutation in a gene that gives them a higher chance to develop cancer than someone without the mutation.

Search Encyclopedia. Autosomal Dominant Inheritance Genes are the blueprints for making proteins.